Essay – A Suggestion that it might be worthwhile to add Gamma Globulin to treatment protocols for Chronic Lyme Disease and Multiple Sclerosis
A) There are three reasons why it might be beneficial to add Gamma Globulin to treatment protocols for Chronic Lyme disease. They are:
Because of these three reasons I am suggesting that Gamma Globulin be empirically tried in recalcitrant cases of Lyme disease in which antibiotic therapy has been found wanting.
Evaluation of these suggestions will be difficult because it will depend on the time honored suggestions of Francis Bacon who in 1620 stated that careful observation will be the best avenue with which to evaluate scientific studies (8). This will occur only if clinicians who try Gamma Globulin in Lyme disease will share their observations with colleagues, patients and their families, through the Internet, and through case reports in the medical literature.
However there are three noninvasive methods by which possible effects of Gamma Globulin on Lyme disease can be evaluated (9,10,11). They are:
I doubt whether these studies will be done in the near future because of their expense, difficulty, and the fact that there are those who have convinced themselves and others that Chronic Lyme disease is not a problem (12). Because of this, I hope that those who might be interested in this suggestion will not delay in acting on it until all these studies are completed.
B) Addendum - As I finished this essay it occured to me that gamma globulin might help Multiple Sclerosis as well as Chronic Lyme Disease. Years ago I had a Multiple Sclerosis clinic, in which Multiple Sclerosis was being treated with immunotherapy (13,14). The advent of Copaxin and Betainterferon made this obselete. Now knowing that Multiple Sclerosis is an autoimmune disease it seems reasonable to try gamma globulin in cases not doing well on Copaxin and/or Betainterferon.
I still am taking care of some of these MS patients so I called one who is allergic to Copaxin and slowly getting worse on Betainterferon. I suggested we try a month of intermuscular gamma globulin, but her response will not be discussed here as a single case study is not a significant sample size.
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